Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 57 0.0 0.577 0.052 0.113
biological_process el 57 0.06 0.966 0.629 0.239
biological_process ka 57 0.0 0.613 0.049 0.113
biological_process rf 57 0.0 0.577 0.052 0.113
cellular_component ct 3 0.0 0.11 0.037 0.051
cellular_component el 3 0.0 0.572 0.192 0.269
cellular_component ka 3 0.002 0.145 0.05 0.067
cellular_component rf 3 0.0 0.11 0.037 0.051
disease ct 15 0.002 0.863 0.2 0.274
disease el 15 0.005 0.806 0.293 0.265
disease ka 15 0.0 0.777 0.197 0.268
disease rf 15 0.002 0.863 0.2 0.274
genetic_interaction ct 51 0.0 1.0 0.41 0.338
genetic_interaction el 51 0.0 1.0 0.406 0.334
genetic_interaction ka 51 0.0 0.302 0.13 0.081
genetic_interaction rf 51 0.0 1.0 0.41 0.338
molecular_function ct 4 0.0 0.381 0.095 0.165
molecular_function el 4 0.473 0.744 0.587 0.099
molecular_function ka 4 0.0 0.348 0.087 0.151
molecular_function rf 4 0.0 0.381 0.095 0.165
pathway ct 27 0.0 0.995 0.07 0.189
pathway el 27 0.0 0.207 0.03 0.054
pathway ka 27 0.0 0.14 0.018 0.031
pathway rf 27 0.0 0.176 0.03 0.048
phenotype ct 15 0.0 0.848 0.27 0.303
phenotype el 15 0.179 0.837 0.445 0.196
phenotype ka 15 0.0 0.932 0.299 0.334
phenotype rf 15 0.0 0.876 0.272 0.306
protein_interaction ct 59 0.0 0.349 0.021 0.062
protein_interaction el 59 0.0 0.39 0.018 0.057
protein_interaction ka 59 0.0 0.032 0.002 0.005
protein_interaction rf 59 0.0 0.325 0.02 0.06

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 59 0.0 0.705 0.087 0.168
integration_mean_by_presence el 59 0.0 0.889 0.052 0.146
integration_mean_by_presence ka 59 0.0 0.556 0.055 0.125
integration_mean_by_presence rf 59 0.0 0.507 0.029 0.085
mean ct 59 0.0 0.593 0.083 0.162
mean el 59 0.0 0.496 0.049 0.118
mean ka 59 0.0 0.542 0.051 0.118
mean rf 59 0.0 0.518 0.038 0.095

CDF plots of non integrated kernels

CDF plots of integrated kernels